[Translation] A multicenter, randomized, double-blind, placebo-controlled, single-dose, dose-escalation phase I clinical study evaluating the safety, tolerability, pharmacokinetics, and pharmacodynamics of ABA001 injection in patients with mild hypertension.
主要目的:
评估ABA001注射液在轻度高血压患者中的安全性与耐受性。
次要目的:
1.评价ABA001注射液的药代动力学(PK)特征。
2.评价ABA001注射液的药效学(PD)特征。
3.评价ABA001注射液对轻度高血压患者收缩压(SBP)和舒张压(DBP)的影响。
探索性目的:
评价ABA001注射液的免疫原性。
[Translation] Primary Objective: To evaluate the safety and tolerability of ABA001 injection in patients with mild hypertension.
Secondary Objectives:
1. To evaluate the pharmacokinetic (PK) characteristics of ABA001 injection.
2. To evaluate the pharmacodynamic (PD) characteristics of ABA001 injection.
3. To evaluate the effects of ABA001 injection on systolic and diastolic blood pressure (DBP) in patients with mild hypertension.
Exploratory Objective: To evaluate the immunogenicity of ABA001 injection.