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April 24th, 2025 — Laekna (2105.HK) announced that the company will present two posters at the 2025 Annual Meeting of the American Association for Cancer Research (AACR), showcasing its internally discovered pre-clinical drug candidates for cancer: LAE118, a pan mutant-selective PI3Kα inhibitor, and LAE122, a novel, potent and selective WRN inhibitor. Both drug candidates target prevalent tumor mutations. LAE118 targets against PI3Kα mutations, which are commonly found in patients with breast, colorectal, endometrial, and numerous other cancers. LAE122 is a novel, potent WRN-selective inhibitor for the treatment of MSI-H tumors, including colorectal, gastric, endometrial, and ovarian cancers. Dr. Justin Gu, Chief Scientific Officer of Laekna, said: “Both LAE118 and LAE122 demonstrate robust in vivo anti-tumor efficacy at doses lower than those of competing compounds. Additionally, LAE118 exhibits exceptional in vitro anti-proliferation activities against both kinase and helical domain mutant cells, with IC50 5 to 10-fold lower than those of competing compounds. This positions LAE118 as a promising candidate, offering patients a more precise and effective innovative therapy”. Dr. Justin Gu emphasized that Laekna’s AI-powered structure-based drug design platform enabled the rapid identification of high-potency candidates with optimized drug-like properties by internal discovery team. The AACR Annual Meeting, the most important cancer meeting in the world, will take place from April 25 to 30, 2025, in Chicago, USA. LAE118: A next-generation PI3Kα inhibitor, potentially best-in-class Three hotspot mutations (H1047R, E545K, E542K) on the p110α subunit of PI3Kα are the recognized activating mutations accounting for more than 1/3 of all PI3Kα mutations. Some pan-mutant selective PI3Kαinhibitors demonstrated improved therapeutic window comparing with orthosteric PI3Kα inhibitors and maintained good clinical responses. However, due to relatively weak potency against PIK3CA helical domain mutants, these inhibitors have less favorable clinical responses in these group of patients. Therefore, there is an urgent need to develop novel pan-mutant selective PI3Ka inhibitors with improved activity against helical domain mutants, which would significantly expand the treatable patient population. LAE118 is a novel allosteric pan-mutant selective PI3Kα inhibitor demonstrating excellent in vitro anti-proliferation activities in both kinase and helical domain mutant cells. LAE118 presents strong anti-tumor efficacy and good PK/PD relationship in GP2D (H1047L), HCC1954 (H1047R), MCF7 (E545K) and MDA-MB-361 (E545K) Xenograft models at doses that are significantly lower than other pan-mutant selective PI3Kα inhibitors. Currently, no pan-mutant-selective PI3Kα inhibitor has been commercialized. With its potentially best-in-class features, LAE118 has emerged as a key player for the next generation of PI3Kα inhibitors. It’s currently in IND enabling stage. LAE122: a novel, potent and selective WRN Inhibitor for the treatment of MSI-H tumors DNA mismatch repair (dMMR) deficiency causes Microsatellite instability (MSI-H), which is frequently observed in various tumor types, including colorectal, gastric, endometrial, and ovarian cancers. Although immune checkpoint inhibitors (ICI) have been approved for the treatment of MSI-H tumors, significant unmet medical need remains across several tumor types that fail to respond or relapse with ICI therapies. Werner syndrome ATP-dependent helicase (WRN) is a RecQ family helicase that plays important roles in DNA repair and in the maintenance of genome integrity. Recent studies have identified WRN as a promising synthetic lethal drug target for MSI-H cancers. LAE122 is a novel, potent and selective WRN inhibitor developed by Laekna through structure-based drug design strategy. LAE122 has highly differentiated structure from bench-mark molecules and displayed single digit nanomolar IC50 values in biochemical assay and cell anti-proliferation assay on MSI-H cells but had no effect on Microsatellite stability (MSS) cells up to 10 µM. LAE122 demonstrated favorable drug-like properties, including good in vitro ADMET and in vivo PK with low plasma clearance and high oral bioavailability across animal species. In SW48 and HCT116 CDX models, LAE122 showed robust anti-tumor growth effect at lower doses than bench-mark molecules with strong evidence on biomarker change. LAE122 didn’t have off-target liability in in vitro assays and demonstrated good tolerability in preclinical toxicology studies. Presentation details are as follows: Poster No.1 Abstract Number: 9661 Poster Number: LB437 Title: LAE118, a Pan Mutant-Selective PI3Kα inhibitor with Strong Anti-tumor Growth Effects in both PIK3CA Kinase and Helical Domain Mutant Xenografts Time: Wednesday, April. 30, 2025, 09:00 a.m. – 12:00 p.m. CST Location: McCormick Place Convention Center, Chicago, Illinois Poster No.2 Abstract Number: 6302 Poster Number: 4192 Title: Preclinical Characterization of LAE122, a Novel, Potent and Selective WRN Inhibitor for the Treatment of MSI-H Tumors Time: Tuesday, April. 29, 2025, 09:00 a.m. – 12:00 p.m. CST Location: McCormick Place Convention Center, Chicago, Illinois – End – Contact Us IR ir@laekna.com Media communication@laekna.com Corporate and Business Development BD@laekna.com About Laekna Stock Code: 2105.HK Founded in 2016, Laekna is a science-driven, clinical-stage biotechnology company committed to bringing novel therapeutics to patients with metabolic diseases, cancer and liver fibrosis around the world. As of December 31, 2024, Laekna has initiated seven clinical trials for LAE102, LAE002 (afuresertib), LAE001 and LAE005 to address unmet medical needs in obesity and cancers. LAE102 is our internally discovered antibody against ActRIIA. Blocking Activin-ActRII pathway could promote muscle regeneration and decrease fat mass, this positions LAE102 as a promising drug candidate for achieving quality weight control. We’ve obtained IND approvals from the FDA and the CDE for LAE102 in obesity indication and are advancing the Phase I clinical trial in China. In November 2024, Laekna entered into a clinical collaboration agreement with Eli Lilly and Company to support and accelerate global clinical development of LAE102 for the treatment of obesity. Laekna team has accumulated tremendous experiences and deep know-how in the specific field of targeting ActRII receptors and is developing more drug candidates (LAE103 and LAE123), in addition to LAE102, to maximize the value of the target. LAE103 is an ActRIIB-selective antibody and LAE123 is a dual inhibitor against ActRIIA/IIB. Both are our internally discovered antibodies for muscle and other disease indications. In the cancer area, Laekna has built a comprehensive portfolio of drug candidates including LAE002(afuresertib), LAE001 and other seven pre-clinical drug candidates. LAE002 (afuresertib) is a potent AKT inhibitor that inhibits all three AKT isoforms (AKT1, AKT2 and AKT3) as well as one of the only two AKT inhibitors in late-stage development for breast and prostate cancer globally. Laekna has commenced the Phase III clinical trial (AFFIRM-205) for LAE002 in patients with HR+/HER2- breast cancer and the study recruitment is on track. Laekna, Inc. (2105.HK) was listed on the Main Board of The Stock Exchange of Hong Kong Limited (the “Hong Kong Stock Exchange”) on June 29, 2023. For more information, please visit: https://www.laekna.com/ or https://www-linkedin-com.sutd.idm.oclc.org/company/74110713/ Forward-Looking Statements This press release may contain certain “forward-looking statements” which are not historical facts, but instead are predictions about future events based on Laekna’s current beliefs, assumptions and expectations, commonly identified by words such as "would", "may", "expects", "believes", "plans", "intends", "projects" and other terms with similar meaning. Although we believe that our predictions are reasonable, future events are inherently uncertain and our actual future results or performance may be materially different from what we expect. Accordingly, you are strongly cautioned that reliance on any forward-looking statements is subject to significant known and unknown risks and uncertainties. All forward-looking statements contained herein are qualified by reference to the cautionary statements set forth in this section. All information provided in this press release is as of the date of this press release and are based on assumptions that we believe to be reasonable as of this date, and we do not undertake any obligation to update any forward-looking statement, except as required under applicable law.

April 23, 2025 — Laekna (2105.HK) a science-driven, clinical-stage biotechnology company, released its 2024 Environmental, Social and Governance (ESG) report. In 2024, Laekna's ESG rating has soared from B+ to A-. The significant advancements we’ve achieved in the past year stem from the synergy of innovation spirit, know-how experience, efficient execution, and humanistic care under the guidance of ESG-driven corporate philosophy. We accelerated clinical trials at full speed while continuing to focus on internal discovery of our drug candidates in metabolic diseases and cancer area. We also actively engaged in the global biopharmaceutical collaboration network. “The past year marked a pivotal year for "Laekna's ESG digital empowerment", said Dr. LU Chris Xiangyang, Chairman and CEO of Laekna. Laekna achieved standardized and transparent governance by launching the OA system and QMS (Quality Management System) At the corporate culture level, digitization conveys positive energy In fulfilling social responsibilities, digitization transcends geographical barriers “If ESG is the cornerstone of a company's sustainable development, then digital empowerment is an engine driving Laekna forward, making R&D more efficient, management more transparent, culture more cohesive, and responsibility more tangible.” Dr. LU stated. Laekna’s ESG Performances Highlights Governance Upgraded the Office Automation (OA) system, improving efficiency and enhancing collaboration Communicated with stakeholders, including investors and shareholders, guided by a transparent, honest, timely, and professional approach Took steps to integrate ESG values into Laekna’s partnerships, aiming to build a resilient, low-risk, and responsible supply chain Innovative R&D Implemented a series of initiatives to strengthen R&D capabilities, including an AI-driven drug discovery platform Established a three-tiered structure comprehensive pharmacovigilance system to identify, evaluate, report and address potential safety risks Filed over 30 patent applications across various jurisdiction Focusing on Talent Launched Laekna Land online as a values-driven recognition and motivation platform, over 120 employees have received recognition at different levels Provided lactation rooms for pregnant and nursing employees, offering safe, hygienic, and private spaces to create a maternity-friendly workplace environment Formulated a series of measures, including the Laboratory Biosafety Management System to protect employees' health and safety Green Operation Identified the six types of climate risks and preliminarily completed the identification, assessment, prioritization, and qualitative financial impact analysis of climate risks Mapped our value chain to understand how climate risks impact current and anticipated business modes Investigated a range of operational methods to minimize the generation of hazardous waste in the laboratory Community Engagement Partnered with the non-profit organization Trash Running to co-host a volunteer trash collection activity Consistently advanced the "Children's Science Innovation Classroom" initiative in Gansu Province to enhance science education philanthropy Launched the "ESG Quick Fill" mini program on internal OA system to facilitate and incentivize employees to participate in volunteer activities - End – Contact Us IR ir@laekna.com Media communication@laekna.com Corporate and Business Development BD@laekna.com About Laekna Stock Code: 2105.HK Founded in 2016, Laekna is a science-driven, clinical-stage biotechnology company committed to bringing novel therapeutics to patients with metabolic diseases, cancer and liver fibrosis around the world. As of December 31, 2024, Laekna has initiated seven clinical trials for LAE102, LAE002 (afuresertib), LAE001 and LAE005 to address unmet medical needs in obesity and cancers. LAE102 is our internally discovered antibody against ActRIIA. Blocking Activin-ActRII pathway could promote muscle regeneration and decrease fat mass, this positions LAE102 as a promising drug candidate for achieving quality weight control. We’ve obtained IND approvals from the FDA and the CDE for LAE102 in obesity indication and are advancing the Phase I clinical trial in China. In November 2024, Laekna entered into a clinical collaboration agreement with Eli Lilly and Company to support and accelerate global clinical development of LAE102 for the treatment of obesity. Laekna team has accumulated tremendous experiences and deep know-how in the specific field of targeting ActRII receptors and is developing more drug candidates (LAE103 and LAE123), in addition to LAE102, to maximize the value of the target. LAE103 is an ActRIIB-selective antibody and LAE123 is a dual inhibitor against ActRIIA/IIB. Both are our internally discovered antibodies for muscle and other disease indications. In the cancer area, Laekna has built a comprehensive portfolio of drug candidates including LAE002(afuresertib), LAE001 and other seven pre-clinical drug candidates. LAE002 (afuresertib) is a potent AKT inhibitor that inhibits all three AKT isoforms (AKT1, AKT2 and AKT3) as well as one of the only two AKT inhibitors in late-stage development for breast and prostate cancer globally. Laekna has commenced the Phase III clinical trial (AFFIRM-205) for LAE002 in patients with HR+/HER2- breast cancer and the study recruitment is on track. Laekna, Inc. (2105.HK) was listed on the Main Board of The Stock Exchange of Hong Kong Limited (the “Hong Kong Stock Exchange”) on June 29, 2023. For more information, please visit: https://www.laekna.com/ or https://www-linkedin-com.sutd.idm.oclc.org/company/74110713/ Forward-Looking Statements This press release may contain certain “forward-looking statements” which are not historical facts, but instead are predictions about future events based on Laekna’s current beliefs, assumptions and expectations, commonly identified by words such as "would", "may", "expects", "believes", "plans", "intends", "projects" and other terms with similar meaning. Although we believe that our predictions are reasonable, future events are inherently uncertain and our actual future results or performance may be materially different from what we expect. Accordingly, you are strongly cautioned that reliance on any forward-looking statements is subject to significant known and unknown risks and uncertainties. All forward-looking statements contained herein are qualified by reference to the cautionary statements set forth in this section. All information provided in this press release is as of the date of this press release and are based on assumptions that we believe to be reasonable as of this date, and we do not undertake any obligation to update any forward-looking statement, except as required under applicable law.

iStock, Jolygon Merck continues to build the case for the pulmonary arterial hypertension drug that won FDA approval in 2024. In high-risk patients with pulmonary arterial hypertension, Merck ’s fusion protein therapeutic Winrevair reduced the likelihood of major morbidity and mortality by 76% in the Phase III ZENITH trial. Analysts at Guggenheim Partners called this outcome “striking” and “very impressive” in a note to investors Monday, pointing to improvements in key secondary outcomes in overall survival and transplant-free survival. The Guggenheim analysts also pointed out that Winrevair had “relatively consistent improvements” in mortality and morbidity across patient subgroups, including age, sex and disease subtype and severity. In November 2024, Merck announced that, following the recommendations of an independent data monitoring board, it was stopping ZENITH ahead of schedule due to “ overwhelming efficacy .” On Monday, the pharma revealed that in the Winrevair arm, 17.4% of patients experienced at least one major morbidity or mortality event, as opposed to 34.7% of placebo comparators. The data were presented at the 2025 American College of Cardiology’s Annual Scientific Session and Expo and simultaneously published in The New England Journal of Medicine . Winrevair is a recombinant activin receptor type IIA-Fc fusion protein that targets and binds to activin A and other ligands that belong to the TGF-β superfamily. This mechanism of action allows Winrevair to restore balanceto vascular proliferation, a key pathway that is altered in pulmonary arterial hypertension (PAH). In particular, PAH patients see high excessive cell proliferation in key arteries, leading to thickened blood vessel walls and, in turn, impaired blood flow. Winrevair was approved by the FDA to treat PAH in March 2024, making it the first-ever drug for the disease that targets activin signaling. Merck continues to build its evidence base for Winrevair. In March 2023, the pharma unveiled full data from the Phase III STELLAR trial, touting a 40.8-meter improvement in 6-minute walk distance in patients with PAH following treatment with the drug. Winrevair also cut the risk of death or clinical worsening by 84% versus placebo. Merck is also running the Phase III HYPERION study to assess the benefit of Winrevair when used with background therapy. In January 2025, the company ended the trial ahead of schedule , in line with the recommendations of an external committee, because of strong efficacy findings in an interim analysis. Results from HYPERION will be presented later this year, according to Merck’s Monday announcement.