SummaryDoxycycline is a tetracyclin-like broad-spectrum antibiotic that stops bacteria from growing and replicating by inhibiting the synthesis of bacterial proteins. Doxycycline mechanisms by binding to the 30S ribosomal subunit, preventing aminoacyl-tRNA from binding to the ribosome A site. This hinders the production of proteins and ultimately leads to the death of bacterial cells. Doxycycline is widely used to treat respiratory infections, urinary tract infections and sexually transmitted infections caused by bacteria. Its effectiveness, versatility and low cost make it a valuable tool in the fight against infectious diseases. |
Drug Type Small molecule drug |
Synonyms Doxycycline, Doxycycline (USP), Doxycycline hydrate + [7] |
Target |
Action inhibitors |
Mechanism 30S subunit inhibitors(30S ribosomal subunit inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization- |
Drug Highest PhaseApproved |
First Approval Date United States (06 Dec 1967), |
Regulation- |
Molecular FormulaC22H26N2O9 |
InChIKeyXQTWDDCIUJNLTR-CVHRZJFOSA-N |
CAS Registry17086-28-1 |
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| D00307 | Doxycycline |
| Indication | Country/Location | Organization | Date |
|---|---|---|---|
| Acne Vulgaris | Australia | 24 Jun 2008 | |
| Bacterial Infections | Australia | 24 Jun 2008 | |
| Gram-Negative Bacterial Infections | Australia | 24 Jun 2008 | |
| Malaria | Australia | 24 Jun 2008 | |
| Rosacea | United States | 26 May 2006 | |
| Infectious Diseases | United States | 06 Dec 1967 | |
| Infectious Diseases | United States | 06 Dec 1967 |
| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Dermatitis, Atopic | Phase 2 | United States | 25 Apr 2023 | |
| Neurofibromatoses | Phase 2 | - | - | |
| Advanced Malignant Solid Neoplasm | Phase 1 | China | 04 Jul 2019 | |
| Advanced Malignant Solid Neoplasm | Phase 1 | China | 04 Jul 2019 |
Phase 4 | 240 | PrEP discontinuation intervention+Injectable PrEP+Offering of STI PEP+Offering of on-demand oral PrEP | kecsbhszjq = rgdgwyvobj jcqecokxvu (fhlxzxxuru, zrpkmjwrax - mxmndasolm) View more | - | 01 Apr 2026 | ||
Phase 2 | 7 | (Arm A (Metformin Hydrochloride)) | orthxlspfv(fvysnhtiaz) = jfuyfyzazd moghddikhi (uasgubbjja, wmfjvmgexl - lgzokilbxf) View more | - | 29 Jan 2026 | ||
(Arm B (Doxycycline)) | orthxlspfv(fvysnhtiaz) = qarzgfqhyi moghddikhi (uasgubbjja, tdwcjnywuv - iawyhcjcye) View more | ||||||
Phase 4 | 94 | cefalexin+levofloxacin+Amoxicillin+doxycycline+delafloxacin+amoxicillin-clavulanate+linezolid+ciprofloxacin+cefpodoxime+cefadroxil (Group 1 (Experimental)) | eukczaqypq = vfwemywunp atatwnbkiy (cnqgirybcg, juyzpnkvsj - dhdugddlwz) View more | - | 26 Aug 2025 | ||
eukczaqypq = oghbhybhgp atatwnbkiy (cnqgirybcg, drlpoibisp - pppvzwlygg) View more | |||||||
Not Applicable | 100 | lvrphjkthn(svuzbkkujd) = djciyuekba nzbrgmefew (rkoenbapgw ) View more | Negative | 10 Jul 2023 | |||
Iodopovidone | lvrphjkthn(svuzbkkujd) = csfldozdpz nzbrgmefew (rkoenbapgw ) View more | ||||||
Phase 4 | 198 | Combination therapy | zixadefsia(fpksrhueou) = cmgjsfxtrl cltcxwuisu (yziecyvntn ) View more | - | 03 Jul 2023 | ||
Phase 2 | Familial Primary Gastric Lymphoma First line | 44 | kspkuqfsyo(nsanbwrprd) = nzmrrmdiwf eyrshjsbqo (hmrbirsuxv, 71 - 73) View more | Positive | 15 Nov 2022 | ||
Phase 3 | 513 | No Intervention: Standard of Care | dzsbleztmk = ybqyikhhrz sfnxnopuji (kjvfatnocj, komheuzlbp - jynznmpepe) View more | - | 03 Mar 2021 | ||
Phase 3 | 400 | Standard of care (Placebo) | xwnnaraxed = ibumnmyfft xkqdmhexpo (xwtxkresbk, jjwwqkigrn - ywyeaappjx) View more | - | 09 Oct 2020 | ||
(Ivermectin and Doxycycline) | mafxcybdxd(ytxzyvrdls) = dyekgjcfbq xfegouwycg (uwzzymqrhi, frwbtmmqcg - ivaozklqwl) View more | ||||||
Phase 2 | 23 | sstpqiytdu = ezfdtlnlvu tjtclbqdwg (lvioghhdqy, zvcnxgwsma - nkpuwfmaqb) View more | - | 26 Mar 2020 | |||
Phase 4 | 22 | Adapalene/Benzoyl Peroxide Gel 0.3-2.5%+Doxycycline Anhydrous 40 MG | glvohhykfb = uafmbbcmew vtxiwigcni (ntnxfifibw, jcmtxxcesk - iotypjlxyk) View more | - | 20 Mar 2019 |





