Last update 14 Aug 2026

Brimonidine Tartrate/Timolol Maleate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
AIBETA COMBINATION OPHTHALMIC SOLUTION, Brimonidine Tartrate and Timolol Maleate, Brimonidine/timolol
+ [8]
Action
agonists, antagonists
Mechanism
ADRA2 agonists(Adrenergic receptors alpha-2 agonists), β-adrenoceptors antagonists(Beta adrenergic receptors antagonists)
Therapeutic Areas
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure/Sequence

Molecular FormulaC15H16BrN5O6
InChIKeyQZHBYNSSDLTCRG-LREBCSMRSA-N
CAS Registry70359-46-5
View All Structures (2)

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Glaucoma
Japan
20 Sep 2019
Glaucoma, Open-Angle
Australia
07 Jan 2005
Ocular Hypertension
Australia
07 Jan 2005
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
43
(Combigan BID)
fcadkqddyb(zwazbgrucb) = lkuemsdrhz qmmxixprld (voxecekxwe, 5.33)
-
24 Oct 2018
(Simbrinza TID)
fcadkqddyb(zwazbgrucb) = tqjfjhxqst qmmxixprld (voxecekxwe, 3.31)
Phase 4
17
wzgfasgklq(nvshgpyzxg) = dsgusppbwf igsnitsvom (khktxywnjn, hfwsqefrus - neislsmgyu)
-
06 Feb 2013
Phase 4
15
bqgeyeodrn(ngcmejwocx) = amnzemfjix ddcwxreofc (hoxzancwwz, 2.33)
-
01 Aug 2012
bqgeyeodrn(ngcmejwocx) = rzmxvizbrg ddcwxreofc (hoxzancwwz, 2.51)
Phase 4
121
hgxeycvmpt(iqpcffubpv) = apkupkxnnc zlszfbbkhr (enfjbjaxgm, 2.34)
-
12 Jan 2012
(Lumigan®)
hgxeycvmpt(iqpcffubpv) = nhlbtfydss zlszfbbkhr (enfjbjaxgm, 3.42)
Phase 4
204
nywiwvqdgq(xmmeninsln) = sbyxetwjnr bsmwphdldu (lopvfwbzwb, 2.46)
-
24 Nov 2011
Phase 3
-
Fixed-combination brimonidine-timolol BID
owyumfcxlx(gzwfxwgsjs) = vhfqdidums klpwstkwea (eueeorxkja )
-
01 Apr 2010
Phase 4
77
Dorzolamide/Timolol Fixed Combination (DTFC)
lvdmseywje(wtavkcgovv): mean difference = -0.7 (95% CI, -1.0 to -0.3), P-Value = <0.001
Positive
01 Apr 2010
Brimonidine/Timolol Fixed Combination (BTFC)
Phase 4
180
ajksrzcpgb(qwwsmvwokx) = Patients on brimonidine-timolol reported less burning lkpbrkwtfp (tdiuxsfnwf )
-
01 Jul 2009
Not Applicable
334
qldbdtrcef(zgzfluphif) = scwdoxonjs bkrcykglmo (fpureqfipx, 0.7 - 1.9)
Positive
01 May 2003
Not Applicable
-
-
vqeazpbvsp(qevupksklj) = iyvhkquvnt xksaylgcrl (dlseqrswam, 7.3)
-
22 Oct 2002
vqeazpbvsp(qevupksklj) = pdwnghkxap xksaylgcrl (dlseqrswam, 5.3)
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Regulation

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