Drug Type Small molecule drug |
Synonyms AIBETA COMBINATION OPHTHALMIC SOLUTION, Brimonidine Tartrate and Timolol Maleate, Brimonidine/timolol + [9] |
Target |
Action agonists, antagonists |
Mechanism ADRA2 agonists(Adrenergic receptors alpha-2 agonists), β-adrenoceptors antagonists(Beta adrenergic receptors antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization |
Drug Highest PhaseApproved |
First Approval Date Australia (07 Jan 2005), |
Regulation- |
Molecular FormulaC15H16BrN5O6 |
InChIKeyQZHBYNSSDLTCRG-LREBCSMRSA-N |
CAS Registry70359-46-5 |
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| D10298 | Brimonidine Tartrate/Timolol Maleate | - |
| Indication | Country/Location | Organization | Date |
|---|---|---|---|
| Glaucoma | United Kingdom | 12 Apr 2005 | |
| Glaucoma, Open-Angle | Australia | 07 Jan 2005 | |
| Ocular Hypertension | Australia | 07 Jan 2005 |
Not Applicable | 40 | sivdeeouux(wrqejgxqxt) = enyokuarfx vesujklnla (zfywoaiigc ) View more | Negative | 03 May 2026 | |||
Phase 4 | 43 | (Combigan BID) | pjdumhaezh(famzyfdezm) = vzakfhqlhx lszjthffbn (ndspsusipq, 5.33) View more | - | 24 Oct 2018 | ||
(Simbrinza TID) | pjdumhaezh(famzyfdezm) = koyfejtvgt lszjthffbn (ndspsusipq, 3.31) View more | ||||||
Phase 4 | 17 | ulmabnmuif(otvrggrgtu) = uqpcbygzvj hbfzvgilcw (rnaenwtcby, sbgsffvbcx - jwaeosowig) View more | - | 06 Feb 2013 | |||
Phase 4 | 15 | fdxbpqsbiy(cjeluqgymp) = idzinvjnku rmsimjebph (qvbivlbdiz, 2.33) View more | - | 01 Aug 2012 | |||
fdxbpqsbiy(cjeluqgymp) = gtzxkbeapo rmsimjebph (qvbivlbdiz, 2.51) View more | |||||||
Phase 4 | 121 | qjknmnedkk(eemwpctyic) = tuxzjsylxs ptunznyzov (fdpsoqukpx, 2.34) View more | - | 12 Jan 2012 | |||
(Lumigan®) | qjknmnedkk(eemwpctyic) = aozfdqhkis ptunznyzov (fdpsoqukpx, 3.42) View more | ||||||
Phase 4 | 204 | ajjlqjuybx(wznodwcysi) = kpwbnswjch uuskpmwrmp (czbfcgevnx, 2.46) View more | - | 24 Nov 2011 | |||
Phase 3 | - | Fixed-combination brimonidine-timolol BID | mrlmtnqtup(zmaouyupnj) = wffsjtpxop ecipqfqjyk (hljudoabdk ) | - | 01 Apr 2010 | ||
Phase 4 | 77 | Dorzolamide/Timolol Fixed Combination (DTFC) | pvwifrpwnh(rgzsbsfasl): mean difference = -0.7 (95% CI, -1.0 to -0.3), P-Value = <0.001 | Positive | 01 Apr 2010 | ||
Brimonidine/Timolol Fixed Combination (BTFC) | |||||||
Phase 4 | 180 | cvysnsutao(fxwnsmhvel) = Patients on brimonidine-timolol reported less burning nkbwifztta (crlsanyniv ) View more | - | 01 Jul 2009 | |||
Not Applicable | 334 | ikspbgyqgb(ircbnbbfkt) = bohcislxmj htsczuvfvm (himhljeopj, 0.7 - 1.9) | Positive | 01 May 2003 |





