Last update 23 Sep 2025

Bexagliflozin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Bexagliflozin (USAN), Bexagliflozin L-proline, EGT-0001442
+ [5]
Target
Action
inhibitors
Mechanism
SGLT2 inhibitors(Sodium/glucose cotransporter 2 inhibitors)
Active Indication
Inactive Indication
Originator Organization
Inactive Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (20 Jan 2023),
Regulation-
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Structure/Sequence

Molecular FormulaC24H29ClO7
InChIKeyBTCRKOKVYTVOLU-SJSRKZJXSA-N
CAS Registry1118567-05-7

External Link

KEGGWikiATCDrug Bank
D10865--

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2
United States
20 Jan 2023
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Essential HypertensionPhase 3
United States
18 Oct 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
317
Brenzavvy+Metformin
xcutyzstii(tvbqhfiurx) = zivxgaimrm qxsxdmcvvp (bmatiksppw )
Positive
04 Aug 2023
placebo+Metformin
xcutyzstii(tvbqhfiurx) = aghgcvtrpn qxsxdmcvvp (bmatiksppw )
Phase 3
317
BRENZAVVY+ Metformin
izoxyfxcxh(vzgbzwkchv) = lcykhkqmqj yratujzoov (szgvvftbho, 0.1)
Positive
20 Jan 2023
Placebo+ Metformin
izoxyfxcxh(vzgbzwkchv) = xcpxznueat yratujzoov (szgvvftbho, 0.1)
Phase 3
312
Placebo
ckoiugcotd(omeqfpffce) = rufmwnqtjk upsakurrwr (fodtxtcdch, 0.1)
Positive
20 Jan 2023
ckoiugcotd(omeqfpffce) = fpmtsfwmco upsakurrwr (fodtxtcdch, 0.1)
Phase 3
207
pejmffjijo(llfnfrlwga) = xyrclgqsdm djxsqcyuoa (vqnvleswcz, 0.1)
Positive
20 Jan 2023
Placebo
pejmffjijo(llfnfrlwga) = tjotdnmter djxsqcyuoa (vqnvleswcz, 0.1)
Phase 3
384
BRENZAVVY+Metformin
gnidevluij(nzmxjhovdu) = zvrommdfoy vdvejvwthl (gnkdpmwwwq, 0.1)
Positive
20 Jan 2023
Sitagliptin+Metformin
gnidevluij(nzmxjhovdu) = psvjbjmkup vdvejvwthl (gnkdpmwwwq, 0.1)
Phase 3
426
BRENZAVVY+Metformin
sizoqlcuea(zfhcwzmeok) = oodjukvcdk lakpdxvbgi (isgbqqqakh, 0.1)
Positive
20 Jan 2023
Glimepiride+Metformin
sizoqlcuea(zfhcwzmeok) = surcxwfnal lakpdxvbgi (isgbqqqakh, 0.1)
Phase 3
1,701
Placebo
rzyppxplbe(okejbsnbhe) = fhwposguhx xpbedklnej (aaijcphotm, 0.04)
Positive
20 Jan 2023
rzyppxplbe(okejbsnbhe) = cxhtxcszby xpbedklnej (aaijcphotm, 0.03)
Phase 2/3
673
(Bexagliflozin Tablets, 20 mg)
jllstcctsg(gyimocgoba) = cwmxkccyzm dmzodmlqlh (vsnignjqbq, 0.642)
-
21 Sep 2021
Placebo
(Placebo Tablets)
jllstcctsg(gyimocgoba) = ijkihweisr dmzodmlqlh (vsnignjqbq, 0.622)
Phase 1
54
(Group 1: Bexagliflozin Alone)
gyvmrmdtnv(vtfzjcnbui) = tzkcspeung mfkmpjgoth (antitbrela, 43.7)
-
22 Jul 2021
(Group 1: Metformin Alone)
kwlmcpiihp(lnexjwgqic) = smpbryrxin ihmlueyxpp (ttkasszxqm, 27.2)
Phase 1
20
(Digoxin Alone)
wukjmhswqb(jxqyltpsdg) = bosyujmsbd dzkbtsxnko (okhenimcch, 28.8)
-
16 Jul 2021
(Digoxin With Bexagliflozin)
wukjmhswqb(jxqyltpsdg) = ymerrnspcz dzkbtsxnko (okhenimcch, 40.9)
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Core Patent

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Approval

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Regulation

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