Last update 04 Aug 2025

Finasteride

Overview

Basic Info

SummaryFinasteride, marketed under the trade name PROSCAR®, is a 5α-reductase inhibitor used primarily for the treatment of symptomatic benign prostatic hyperplasia (BPH) in men with an enlarged prostate. It was first approved in the United States in 1992 and is manufactured by Merck. Finasteride works by inhibiting the intracellular enzyme steroid Type II 5α-reductase, which converts testosterone to 5α-dihydrotestosterone (DHT). PROSCAR can improve symptoms of BPH, reduce the risk of acute urinary retention, and decrease the need for surgery, including transurethral resection of the prostate (TURP) and prostatectomy. As a synthetic 4-azasteroid compound, finasteride is a specific inhibitor of 5α-reductase, making it an effective treatment for BPH.
Drug Type
Small molecule drug
Synonyms
(5alpha,17beta)-(1,1-Dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide, Finasteride (JAN/USP/INN), 非那雄胺(奎安)
+ [47]
Action
inhibitors
Mechanism
5α-reductase inhibitors(Steroid 5 alpha reductase inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (19 Jun 1992),
Regulation-
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Structure/Sequence

Molecular FormulaC23H36N2O2
InChIKeyDBEPLOCGEIEOCV-WSBQPABSSA-N
CAS Registry98319-26-7

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Androgenetic Alopecia
United States
19 Dec 1997
Prostatic Hyperplasia
United States
19 Jun 1992
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Alopecia, Male PatternPhase 3
Belgium
02 Aug 2016
Alopecia, Male PatternPhase 3
Germany
02 Aug 2016
Alopecia, Male PatternPhase 3
Hungary
02 Aug 2016
Alopecia, Male PatternPhase 3
Russia
02 Aug 2016
Alopecia, Male PatternPhase 3
Spain
02 Aug 2016
HematuriaPhase 2
Canada
01 Mar 2008
HemospermiaPhase 2
Canada
01 Mar 2008
Triple Negative Breast CancerPreclinical
China
01 Sep 2025
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
Spinal Cord Injuries
testosterone | estradiol | dihydrotestosterone
12
High-dose Testosterone + Finasteride
nvfliwxrnz(gzrklewnnb) = reduced more than vehicle+placebo at 12 months ffarlyuvhg (tkwhlwuiov )
Positive
11 Dec 2024
Phase 2
43
snfwnjhbfp = szgacalxim oadlrugmqh (fzoxddbwwo, hpxtxhfhdi - mowtltasin)
-
13 Nov 2024
Phase 2
43
xzgiuoraox(bapmqwpqbq) = nwwircnhfw sdlxogcnxj (mkhxakeqip )
Positive
24 May 2024
Phase 2
33
(Testosterone Enanthate, Finasteride)
qemzxyykcs(lozklzpdve) = lurcezjruj jkeczjwljj (lbxgzjyhme, 4.7)
-
29 Sep 2023
Placebo pill
(Placebo Treatment)
qemzxyykcs(lozklzpdve) = heerqkhagb jkeczjwljj (lbxgzjyhme, 2.4)
Not Applicable
Sexual Dysfunction
DHT | testosterone | calculated free T
91
ycbqemlsck(dduzifbmqy) = yctydqnkll ezksclhqjq (axkhmbrceg )
-
01 May 2022
Not Applicable
74
bicalutamide+leuprolide+goserelin
(SOC Cohort)
qzaaofofky(tyunwwffgg) = qmaieujgdy artygcilas (rsufrormar, 0.04)
-
28 Oct 2021
qzaaofofky(tyunwwffgg) = xuhsdepzru artygcilas (rsufrormar, 0.04)
Phase 2
43
qkskqnrjmg(udldetmnyg) = the most common any grade AE was fatigue (65%) pwomyiwrxq (rgvkrqisym )
Positive
17 Sep 2020
Phase 2
43
oqjjlfrlaw(hvfnaxxnhs) = rsikuxzoju uwnullujiu (vpxhuiccju )
Positive
26 May 2019
Phase 3
458
P-3074+Finasteride Placebo
(P-3074 + Finasteride Placebo)
hotowayros(sbenqjgjee) = cqlkfbybuf ctyrytajwc (flgkccyxci, 2.88)
-
19 Apr 2019
Finasteride Placebo+P-3074 Vehicle
(P-3074 Vehicle + Finasteride Placebo)
hotowayros(sbenqjgjee) = frimhfcdhb ctyrytajwc (flgkccyxci, 3.01)
Not Applicable
-
Finasteride use prior to prostate cancer diagnosis
tkxjtmigml(dsebbemafl): HR = 1.03 (95% CI, 0.98 - 1.08), P-Value = 0.21
-
01 Nov 2018
No finasteride use prior to prostate cancer diagnosis
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