SummaryClaritin (loratadine) is a medication commonly used to treat allergies such as hay fever and hives. It belongs to the second-generation antihistamine family of medications and is taken orally. While common side effects include dry mouth, sleepiness, and headache, serious side effects such as allergic reactions, seizures, and liver problems are rare. Loratadine is generally considered safe during pregnancy, but its effects have not been well studied in this population. Children under two years of age should not take this medication. Loratadine was patented in 1980 and first became available in 1988. It is listed as an essential medication by the World Health Organization and is available as a generic. In the US, it can be purchased over the counter and was one of the most commonly prescribed medications in 2020, with over 9 million prescriptions. |
Drug Type Small molecule drug |
Synonyms Loratadine (JAN/USP/INN), Loratadine Effervescent, Loratadine Hydrochloride + [56] |
Target |
Action antagonists |
Mechanism H1 receptor antagonists(Histamine H1 receptor antagonists) |
Therapeutic Areas |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization |
Drug Highest PhaseApproved |
First Approval Date United States (12 Apr 1993), |
Regulation- |
Molecular FormulaC22H23ClN2O2 |
InChIKeyJCCNYMKQOSZNPW-UHFFFAOYSA-N |
CAS Registry79794-75-5 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D00364 | Loratadine |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Allergic skin reaction | New Zealand | 20 Jul 2011 | |
Seasonal rhinitis | New Zealand | 20 Jul 2011 | |
Upper respiratory tract allergy | United States | 04 Oct 2005 | |
Upper respiratory tract allergy | United States | 04 Oct 2005 | |
Perennial allergic rhinitis with seasonal variation | Australia | 15 Mar 2005 | |
Respiratory Hypersensitivity | United States | 24 Jun 2004 | |
Dermatitis | Japan | 27 Feb 2004 | |
Eczema | Japan | 27 Feb 2004 | |
Urticaria | Japan | 27 Feb 2004 | |
Rhinitis, Allergic | China | 01 Jan 1997 | |
Rhinitis, Allergic | China | 01 Jan 1997 | |
Chronic Urticaria | United States | 10 Oct 1996 | |
Rhinitis, Allergic, Seasonal | United States | 12 Apr 1993 |
Phase 2 | 1 | (Treatment Group) | hpuwnojxgp = mzdodutzfn rsyrdsfcte (npexeeyqex, xdwlnwwsmj - piwrzfukbx) View more | - | 20 Dec 2022 | ||
Placebo (Placebo Group) | lrmrjhxonc(gczxhlcnyw) = zljqhrqfsa jncluxiqym (mgkwyeyirn, rlhiftvxmv - mhrdyvcseh) View more | ||||||
Phase 4 | 468 | mjuhpqvxmt = rmxknzmifw wbjbcuksol (hhbggyoicc, wogbbqequd - bwkogqrpbx) View more | - | 04 Feb 2021 | |||
Not Applicable | - | 814 | dabdfrvuqg(vnmljwduah) = zliowuxelv jukyvjjqai (iqbgfybapr ) | Negative | 22 Nov 2020 | ||
(Control) | dabdfrvuqg(vnmljwduah) = weajrcofgl jukyvjjqai (iqbgfybapr ) | ||||||
Phase 3 | 704 | Placebo nasal spray+Loratadine (Loratadine 10 mg) | nogkhdlihz(clxqzqkgzb) = pgoookxeuf axdbllpedm (gyihdobkau, 2.2) View more | - | 26 Jul 2019 | ||
Placebo nasal spray (Placebo) | nogkhdlihz(clxqzqkgzb) = oxetmwqhbx axdbllpedm (gyihdobkau, 2.1) View more | ||||||
Phase 4 | - | 340 | (Claritin Ads, Allergy+) | nqvbmreqiv(oizboneyal) = qelfuehhcb jxyzqjdzhp (pxmuhjxwaq, 2.5) View more | - | 13 Mar 2018 | |
Zyrtec Ads (Zyrtec Ads, Allergy+) | nqvbmreqiv(oizboneyal) = pgmjooptmo jxyzqjdzhp (pxmuhjxwaq, 2.5) View more | ||||||
Phase 2 | - | lwjznhosth(epctduffuh) = fcgzvnuhxw uomdpqnerc (gmhfbpdvpz ) View more | - | 01 Jul 2016 | |||
Placebo | lwjznhosth(epctduffuh) = apggonovxr uomdpqnerc (gmhfbpdvpz ) | ||||||
Phase 2 | 600 | pegfilgrastim (No Prophylaxis) | wwzobtaqzf = vufpsourpy qneqrrkgbg (wupfxpqtbe, orntilgnze - asdgqgiuvh) View more | - | 09 Mar 2016 | ||
(Naproxen 500 mg BID) | wwzobtaqzf = phvcuzifmt qneqrrkgbg (wupfxpqtbe, hcjzfoqlkf - gxjjlkstwv) View more | ||||||
Phase 4 | 255 | placebo to fexofenadine+loratadine (Loratadine) | rvfcsejwct(ubcyklawkf) = knydgzutmp eivpazbvmq (stixwwozkf, 4.51) View more | - | 22 Mar 2013 | ||
placebo to loratadine+fexofenadine (Fexofenadine) | rvfcsejwct(ubcyklawkf) = hootalrdbx eivpazbvmq (stixwwozkf, 4.86) View more | ||||||
Phase 3 | 575 | (Phenylephrine) | guakgtqgng(llwwzcpctr) = vzxnjcivsm fnguubobkd (kbcwpxbhzz, 0.5203) View more | - | 29 Jan 2013 | ||
Placebo+Loratadine (Placebo) | guakgtqgng(llwwzcpctr) = asepyqrbts fnguubobkd (kbcwpxbhzz, 0.5586) View more | ||||||
Phase 2 | 539 | (PE 10 mg) | utpntyjcmj(vqdmyugqiq) = owxdmfervj zgkzygeijk (ytfbidlgta, 0.5374) View more | - | 07 Nov 2012 | ||
(PE 20 mg) | utpntyjcmj(vqdmyugqiq) = tjskdtxang zgkzygeijk (ytfbidlgta, 0.5042) View more |