This randomized, controlled clinical trial investigates the potential cardioprotective effects of melatonin in women diagnosed with peripartum cardiomyopathy (PPCM). The study aims to determine whether melatonin supplementation improves left ventricular (LV) function, promotes reverse remodeling, and reduces systemic inflammation. Participants receive standardized heart failure therapy with or without adjunctive melatonin, and outcomes are assessed using echocardiographic parameters (including LVEF, LV dimensions, and global longitudinal strain) and inflammatory biomarkers (e.g., CRP, IL-6, TNF-α). The study hypothesizes that melatonin's antioxidant and anti-inflammatory properties will enhance cardiac recovery, improve functional capacity, and potentially reduce morbidity in PPCM patients.

Start Date20 Dec 2026

Sponsor / Collaborator

Tanta University

[+1]

TCTR20260327005

/ Not yet recruitingPhase 2IIT

The effects selenium supplementation combined with herbal sauna on ankle brachial index and blood lipid profiles among people with dyslipidemia

Start Date01 May 2026

Sponsor / Collaborator

Burapha University

IRCT20251109067930N1

/ SuspendedPhase 2/3IIT

Studying the effect of oral selenium on the size of non-malignant thyroid nodules

Start Date21 Dec 2025

Sponsor / Collaborator-

100 Clinical Results associated with Selenium

100 Translational Medicine associated with Selenium

100 Patents (Medical) associated with Selenium

14,269

Literatures (Medical) associated with Selenium

01 Dec 2026·MOLECULAR BIOLOGY REPORTS

Selenium alleviates Staphylococcus aureus-induced mastitis by modulating mitochondrial dynamics and inhibiting the ROS/NLRP3/Pyroptosis pathway

Article

Author: Zhang, Junhao ; Hu, Changmin ; Du, Yanting ; Yang, Jinghan ; Hu, Yanjun ; Qi, Xue ; Jiang, Mingxuan

BACKGROUND:

The pathogenesis of bovine mastitis involves inflammation and cell death, with pyroptosis being a key factor in its development. Currently, antibiotics remain the primary therapeutic option for bovine mastitis, however, the increasing prevalence of antibiotic resistance constitutes a major public health threat. Selenium (Se) has been reported to alleviate inflammation primarily through its antioxidant properties, but the mechanism by which Se regulates pyroptosis in bovine mastitis remains unclear.

METHODS AND RESULTS:

In this study, an in vitro mastitis model was established by infecting MAC-T cells with inactivated Staphylococcus aureus (S. aureus) (MOI = 10, 12 h). The results revealed that the mitochondrial membrane potential of the MAC-T cells in the infection group decreased significantly. Moreover, the accumulation of Reactive oxygen species (ROS) was accompanied by the activation of NOD-like receptor family containing pyrin domain 3 (NLRP3), the expression of the pyroptosis-related genes gasdermin D amino terminal fragment (GSDMD-N), and cysteine aspartate specific protease 1 (cleaved-caspase 1). Pretreatment with Se, the NLRP3 inhibitor MCC950 and the antioxidant N-acetylcysteine (NAC) attenuated mitochondrial damage, ROS accumulation, and the inhibition of pyroptosis. An in vivo mastitis model was established in mice fed a high-selenium diet (containing 1.5 mg/kg Se) and intramammarily injected with inactivated S. aureus (1 × 10⁸ CFU/mL). Histological analysis revealed intact alveolar structure and reduced inflammatory cell infiltration in mice fed the high-selenium diet. The expression of the inflammasome NLRP3 downregulated, and the expression of GSDMD-N, a direct executor of pyroptosis, upregulated.

CONCLUSION:

Our in vitro and in vivo results confirmed that Se alleviate mitochondrial damage and pyroptosis by inhibiting the NLRP3 pathway, ultimately alleviating mastitis.

01 Jun 2026·VETERINARY RESEARCH COMMUNICATIONS

Role of selenium in cow fertility and reproduction—A review

Review

Author: Partyka, Agnieszka ; Feng, Heze ; Adeniran, Samson O ; Kayode, Omowumi T ; Fagbenro, Silas O ; Zheng, Peng

01 Jun 2026·Bioactive Materials

A mitochondria-targeted nanoantioxidant restores alveolar bone homeostasis in periodontitis by quenching ROS and suppressing the cGAS-STING pathway

Article

Author: Zheng, Ao ; Jiang, Xinquan ; Wang, Xiao ; Cao, Lingyan ; Huang, Ning ; Xu, Yue ; Pan, Lisha

Prolonged periodontal inflammation and progressive alveolar bone loss are typical manifestations of periodontitis. Antioxidative therapies targeting the central role of reactive oxygen species (ROS) have been explored, but lack of subcellular specificity limits efficacy. Mitochondria function as an upstream redox hub that drives oxidative stress, inflammatory responses, and alveolar bone resorption, making mitochondrial redox modulation a promising yet underexplored strategy for periodontitis therapy. Herein, we developed a mitochondria-targeted, redox-responsive nanocomposite (TC/pSeSe) that enables programmable redox modulation of the pathological periodontal microenvironment. The antioxidative core consists of a ROS-responsive diselenide-containing copolymer (pSeSe) capable of selenium release, while the triphenylphosphine/chitosan (TC) coating confers mitochondrial-targeted, controlled redox activity, mucosal retention and cationic antibacterial properties. With preferential mitochondrial localization, TC/pSeSe undergoes diselenide bond cleavage and selenium release under oxidative stress, thereby restoring mitochondrial redox homeostasis and attenuating downstream mitochondrial DNA (mtDNA)-cGAS-STING-mediated inflammatory signaling. Through combined ROS scavenging and selenium-mediated support, TC/pSeSe mitigates ferroptosis in a partially glutathione peroxidase 4 (GPX4)-dependent manner and restores osteogenic potential in bone marrow-derived stem cells. In parallel, TC/pSeSe exhibits antibacterial activity against periodontal pathogens through combined selenium and the cationic TC coating functionalities. In vivo, TC/pSeSe restored alveolar bone regeneration and attenuated periodontal inflammation. Collectively, this study proposes a mitochondria-centered redox modulation strategy, providing a comprehensive and promising therapeutic approach for periodontitis treatment.

News (Medical) associated with Selenium

05 May 2026

·www.prnewswire.com

Support Egg Quality and Ovulation with Nature's Bounty® New Fertility Supplement*

Nature's Bounty® Fertility Support Supplement Brings Together Clinically Studied Nutrients in a Carefully Curated Formula for this Important Life Stage BRIDGEWATER, N.J., May 5, 2026 /PRNewswire/ -- Nature's Bounty®, a leader in scientifically backed vitamin and nutritional supplements, today announced its thoughtfully curated Fertility Support supplement that features NAC (N-Acetyl Cysteine), selenium and vitamin E. These clinically studied nutrients are shown to support egg quality, ovulation, fertilization and implantation during a woman's reproductive health journey.* Nature's Bounty Fertility Support is available now on Amazon.com. Continue Reading Nature's Bounty Fertility Support supplement features NAC (N-Acetyl Cysteine), selenium and vitamin E. These clinically studied nutrients are shown to support egg quality, ovulation, fertilization and implantation during a woman’s reproductive health journey.* "The journey to parenthood can be deeply personal and biologically complex, and many women are seeking trusted, science-backed ways to nourish their bodies during this life stage," said Abby Klosterbuer, Director of Medical Affairs, Nature's Bounty®. "Throughout the product development process, we evaluated the latest nutrition research to create a formula that is grounded in science. For instance, we included NAC because it's a building block for the body's primary antioxidant, glutathione, helping support oxidative balance important for healthy ovarian and uterine function. We designed the new Fertility Support supplement to be evidence-based and accessible, so more women can confidently add fertility nutrition into their daily routines as they plan for parenthood." Nature's Bounty Fertility Support capsules include: NAC (N-Acetyl Cysteine), a powerful antioxidant clinically shown to support ovulation and a healthy uterine lining that are foundational for healthy fertilization and implantation.* CoQ10, an antioxidant naturally found in every cell, including eggs, that plays an important role in cellular energy for egg quality.* Selenium and vitamin E, vital nutrients clinically shown to support healthy follicles, which promotes ovulation and helps support the growth and maturation of eggs.* Vitamin D, an essential vitamin necessary for several aspects of overall reproductive health and function.* To learn more about Nature's Bounty, please visit . About Nature's Bounty® For more than 50 years, the Nature's Bounty® brand has been focused on enhancing the health and wellness of peoples' lives. Nature's Bounty® vitamin and nutritional supplements are overseen by scientists, manufacturing specialists and quality experts, each one dedicated to maintaining high quality standards. We only use ingredients from suppliers that meet our stringent Quality Assurance Standards, as well as GMP supplement quality standards. By combining the latest breakthroughs in nutritional science with great ingredients, we're proud to provide consumers with supplements of outstanding quality and value. For more information, please visit and follow us on Facebook and Instagram. Fertility Support includes ingredients that support ovulation, fertilization and implantation which are all processes involved in conception. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Media Contact Andrea Martin [email protected] SOURCE Nature's Bounty 21% more press release views with Request a Demo

31 Mar 2026

·www.prnewswire.com

Axiota Animal Health Names Wamego, Kansas, as Global Headquarters

Move strengthens the KC Animal Health Corridor as a hub for animal health excellence WAMEGO, Kan., March 31, 2026 /PRNewswire/ -- Axiota Animal Health, global leader in cattle health solutions, announced today it will name its facility in Wamego, Kansas, as the company's global headquarters. The announcement formalizes the longstanding presence of Axiota Animal Health in Wamego, where the company operates manufacturing, research and development, and scientific operations for its products used by cattle producers in more than 30 countries worldwide. "Wamego has long been a cornerstone of Axiota's manufacturing and research, so designating it as our global headquarters is a natural next step," said William (Bill) Weldon, CEO, Axiota Animal Health. "From here, we're developing and producing technologies that help cattle producers around the world improve herd health and productivity. Leveraging our location within the KC Animal Health Corridor and our longstanding relationship with Kansas State University allows us to drive innovation and attract the top talent the industry demands." Located near Kansas State University, the facility benefits from proximity to one of the nation's leading veterinary and animal health research institutions. That connection helps Axiota attract specialized scientific talent and collaborate with researchers advancing the future of livestock health. From its Wamego facility, Axiota supports cattle producers worldwide in improving herd health and performance through prevention-based, non-antibiotic solutions. This includes: Lactipro®, the only rumen-native probiotic that delivers Mega e®, proven to promote rumen health and performance. Multimin® 90 (zinc, copper, manganese and selenium injection) is the only FDA-approved injectable supplement that delivers four trace minerals known to support cattle health and reproduction. The decision highlights the global impact of the KC Animal Health Corridor, a hub stretching from Manhattan, Kansas, to Columbia, Missouri, with Kansas City at its heart. The region, home to the world's largest concentration of animal health assets, serves as a leading center for life science research, development and collaboration. "Axiota's decision to locate its global headquarters in Wamego reflects the industry leadership that continues to define the Corridor," said Kimberly Young, president of the KC Animal Health Corridor. "Companies here aren't just participating in the industry — they're driving the science, technology and production that support animal health and food security around the world." About Axiota Animal Health Axiota Animal Health is an innovation-driven company that discovers, develops and markets products for beef and dairy producers around the world. Axiota's non-antibiotic solutions prepare cattle to thrive during transition and stress and support producers' goals of optimal health, performance and animal well-being. | axiota.com About KC Animal Health Corridor Representing more than half of the global animal health industry's sales, and home to over 300 animal health companies, the KC Animal Health Corridor is the largest concentration of its kind worldwide. An initiative of the Kansas City Area Development Council, the Corridor is anchored by Manhattan, Kansas, and Columbia, Missouri, and serves as a thriving hub for innovation and collaboration. | kcanimalhealth.com SOURCE Axiota® Animal Health 21% more press release views with Request a Demo

29 Mar 2026

·www.drugs.com

Study Links High Antioxidant Intake To Changes in Offspring Development

SUNDAY, March 29, 2026 — Antioxidants are often seen as a good, simple way to boost health, but taking too many may come with some risks, new research suggests. A study from Texas A&M University found that high doses of certain antioxidants may affect sperm and lead to developmental changes in offspring. The research, published recently in the journal Frontiers in Cell and Developmental Biology , focused on two antioxidants: N-acetyl-L-cysteine (NAC) and selenium. Male mice given these supplements for six weeks went on to have offspring with noticeable changes in skull and facial structure. The fathers themselves appeared healthy, researchers said. The study suggests that too many antioxidants may alter sperm DNA, which could affect how offspring develop. "We know alcohol causes oxidative stress and we were looking to push back on it by adding a supplement known to lower oxidative stress," said lead researcher Dr. Michael Golding , a professor in the Department of Veterinary Physiology & Pharmacology at Texas A&M University. "When we realized that offspring born to males that had only been given NAC were displaying skull and facial differences, it was a surprise because this molecule is universally thought to be good," he added in a news release. While the results of research in animals are not always the same in people, the findings raise concerns for men who regularly take high-dose supplements, especially for those planning to have kids. Antioxidants like NAC are widely used and are often included in multivitamins. But more is not always better, experts said. "When we sat down to think it through, we realized that it makes sense — you take a multivitamin to ensure that you're in balance, but if the thing that you're taking to ensure you're in balance is unbalanced (the dose of antioxidants is too high), then you're not doing a good thing," Golding said. Previous research has also found that very high antioxidant intake can reduce the benefits of exercise and affect athletic performance. "Sperm health is another performance metric; it’s just not one that we think about in everyday life," Golding added. Researchers also noticed stronger physical changes in female offspring, including smaller skulls and closer-set eyes. These traits are oftentimes linked to conditions like fetal alcohol syndrome, the researchers said. "There's a very commonly accepted truism in pediatric medicine that the face mirrors the brain, because the brain and the face form at the same time," Golding said. "So, if you see abnormalities in the midline of the face, you're probably going to see midline abnormalities in the brain," he added. Researchers said it’s still unclear whether these changes affect brain function. The findings show that even supplements that are considered healthy can cause harm if taken in such large amounts. And many supplements contain these very high doses. "If your vitamins are providing 1,000% of the recommended daily amount, you should be cautious," he said. "If you stick to the 100% range, then you should be OK." Sources Texas A&M University, news release, March 27, 2026

100 Deals associated with Selenium

R&D Status

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Acquired Immunodeficiency Syndrome	Phase 3	Brazil	Fundação Oswaldo Cruz	31 Oct 2008
Cardiotoxicity	Phase 3	Brazil	Fundação Oswaldo Cruz	31 Oct 2008
Chagas Disease	Phase 3	Brazil	Fundação Oswaldo Cruz	31 Oct 2008
Chronic Disease	Phase 3	Brazil	Fundação Oswaldo Cruz	31 Oct 2008
end organ damage	Phase 3	Brazil	Fundação Oswaldo Cruz	31 Oct 2008
Functional disorder	Phase 3	Brazil	Fundação Oswaldo Cruz	31 Oct 2008
Huntington Disease	Phase 3	Brazil	Fundação Oswaldo Cruz	31 Oct 2008
Infarction	Phase 3	Brazil	Fundação Oswaldo Cruz	31 Oct 2008
Keshan Disease	Phase 3	Brazil	Fundação Oswaldo Cruz	31 Oct 2008
Myocardial Infarction	Phase 3	Brazil	Fundação Oswaldo Cruz	31 Oct 2008

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT01611896 (GRASS, Pubmed \| Eur Thyroid J)	Not Applicable	Graves Disease	430	Selenium supplementation	ykbhedvexy(xxdfevhkkc) = ktsrbpbtzx sgvdvyiiwk (tifjrkdjsl )	Negative	12 Dec 2025
				Placebo	ykbhedvexy(xxdfevhkkc) = uukoqqxitq sgvdvyiiwk (tifjrkdjsl )
AACR2018	Phase 1	Female Genital Neoplasms	-	Selenious acid/carboplatin/paclitaxel	jliwcbatdh(kudeuedfcn) = eshhcxdima ezhuydwxvl (obofxevgui ) View more	-	01 Jul 2018
ASCO2014	Not Applicable	Second Primary Neoplasms	-	Selenium	vpgdhdlbfh(uvwiqakokx) = szhtpvvona afwqyooikf (ztxkettcsb, 0.77 - 2.38)	-	20 May 2014
				Placebo	vpgdhdlbfh(uvwiqakokx) = rihayhlecj afwqyooikf (ztxkettcsb )
Pubmed \| Cochrane Database Syst Rev	Not Applicable	Hashimoto Disease	463	Selenium supplementation	xwbnvhhihk(btshakivfk): RR = 4.67 (95% CI, 1.61 - 13.5), P-Value = 0.004	-	06 Jun 2013
				Selenium
ASCO 12010 \| ASCO 22010	Phase 3	Non-small cell lung cancer stage I	-	selenium (Se) supplementation (Selenized yeast 200 micrograms)	eisprjifxu(dugncibluh) = bgigjookhj qohpnennqm (qhtazldiat ) View more	Negative	20 Jun 2010
				Placebo	eisprjifxu(dugncibluh) = glukkbgxpj qohpnennqm (qhtazldiat ) View more
German Working Group on Trace Elements and Electrolytes (ASTRO2009)	Phase 2	Head and Neck Neoplasms selenium deficiency	40	Selenium supplementation	imrinskzjg(heidbsefph) = kfwltiwtqp nwelvktwxz (evoolvlegb ) View more	Negative	01 Nov 2009
				Control group (no selenium supplementation)	imrinskzjg(heidbsefph) = tdptljiuja nwelvktwxz (evoolvlegb ) View more
ASCO2009	Phase 2	Head and Neck Neoplasms	39	selenium (Group A)	dgrkylrmwv(iejycfxtez) = fwwuadutek lymweodqtu (jqlswwdslx ) View more	Negative	20 May 2009
				selenium (Group B)	dgrkylrmwv(iejycfxtez) = aekzkyjbcr lymweodqtu (jqlswwdslx ) View more
ASCO2008	Phase 2	Prostatic Cancer	140	Placebo	yogvrudtcs(mdddjzzogd) = aoelejmatl mmyqdzjifx (nkwywqtewb )	Negative	20 May 2008
				200µg/day Selenium	yogvrudtcs(mdddjzzogd) = bhmlwniqhh mmyqdzjifx (nkwywqtewb )

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Deal

Boost your decision using our deal data.

view full example data

Core Patent

Boost your research with our Core Patent data.

view full example data

Clinical Trial

Identify the latest clinical trials across global registries.

view full example data

Approval

Accelerate your research with the latest regulatory approval information.

view full example data

Regulation

Understand key drug designations in just a few clicks with Synapse.

view full example data

AI Agents Built for Biopharma Breakthroughs

Accelerate discovery. Empower decisions. Transform outcomes.

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

Selenium

Overview

Basic Info

Related

R&D Status

Clinical Result

Translational Medicine

Deal

Core Patent

Clinical Trial

Approval

Regulation