Hydromorphone Hydrochloride

New York: Drugmakers plan to raise U.S. prices on at least 350 branded medications including vaccines against COVID, RSV and shingles and blockbuster ⁠cancer treatment Ibrance, even as the Trump administration pressures them for cuts, according to data provided exclusively by healthcare research firm 3 Axis Advisors . The number of price increases for 2026 is up from the same point last year, when drugmakers unveiled plans for raises on more than 250 drugs. The median of this year's price hikes is around 4% - in line ‌with 2025. The increases do ‌not reflect any rebates to pharmacy benefit managers and other discounts. DRUGMAKERS ALSO CUT SOME PRICES Drugmakers also plan to cut the list prices on around nine drugs. That includes a more than 40% cut for ‌Boehringer Ingelheim's diabetes drug Jardiance and three related treatments. Boehringer Ingelheim and Eli Lilly, which sell Jardiance together, did not immediately respond to requests for comment on the reason for the price cuts. Jardiance is among the 10 drugs for which the U.S. government negotiated a lower price for the Medicare program for people aged 65 and older in 2026. Under those negotiations, Boehringer and Lilly slashed the Jardiance price by two-thirds. U.S. patients currently pay by far the most for prescription medicines, often nearly ​three times more than in other developed nations, and Trump has been pressuring drugmakers to lower ​their prices to what patients pay in similarly wealthy nations. The increases on 350 medicines come even as Trump has struck deals with 14 ‌drugmakers on prices of ‍some of their medicines for the government's Medicaid program for low-income Americans and for cash payers. Pfizer, Sanofi, Boehringer Ingelheim, Novartis ‍and GSK are among those companies and also plan to raise prices on some drugs on ‌January 1. "These deals are being announced as transformative when, in fact, they really just nibble around the margins in terms of what is really driving high prices for prescription drugs in the U.S.," said Dr. Benjamin Rome, a health policy researcher at Brigham and Women's Hospital in Boston. Rome said the companies seem to be maximizing prices while negotiating discounts behind the scenes with health and drug insurers and then setting yet another price for direct-to-consumer cash-pay sales. An HHS spokesman declined to comment. KEEPING UP WITH INFLATION Pfizer announced the most list price hikes, on around 80 different drugs including cancer drug Ibrance, migraine pill Nurtec, and COVID treatment Paxlovid, as well as some administered in hospitals such as morphine and hydromorphone. Most of Pfizer's increases ‍are below 10%, except for a 15% hike of COVID vaccine Comirnaty, while some of its relatively inexpensive hospital drugs saw more than four-fold increases. Pfizer said in a statement it had adjusted the average list price of its innovative medicines and vaccines ‍for 2026 below the ⁠overall rate of inflation. "The modest increase is ⁠necessary to support investments that allow us to continue to discover and deliver new medicines as well as address increased costs throughout our business," the company said. Larger U.S. drug price increases were once far more common. Drugmakers have scaled them back due to criticism from lawmakers and new government policies, such as penalizing companies that charge Medicare program prices that rise faster than inflation. European drugmaker GSK plans to increase prices on around 20 drugs and vaccines from 2% to 8.9%. The drugmaker said it is committed to reasonable prices and the hikes are needed to support scientific innovation. Sanofi and Novartis did not respond to requests for comment. More price hikes and cuts can be expected in early January, which is historically the biggest month for drugmakers to raise prices. 3 Axis is a consulting firm that works with pharmacist groups, health plans and some pharmaceutical industry-related groups on drug pricing and supply chain issues. It is a related entity to, and shares staff with, drug pricing non-profit 46brooklyn. (Reporting by Michael Erman ; editing by Caroline Humer)

THURSDAY, Dec. 11, 2025 -- The American Headache Society has updated the guidelines on the use of parenteral pharmacologic therapies for management of migraine attacks in the emergency department; the update was published online Dec. 1 in Headache . Jennifer Robblee, M.D., from Dignity Health in Phoenix, and colleagues conducted a systematic review and meta-analysis to update the 2016 American Headache Society guidelines on parenteral pharmacologic therapies for management of migraine attacks. Eligible studies were randomized controlled trials (RCTs) involving adults diagnosed with migraine, treated with intravenous (IV), intramuscular, subcutaneous, or nerve block (including sphenopalatine ganglion [SGP] block) interventions in the emergency department. Twenty-six new RCTs evaluating 20 injectable treatments were identified. Of these, 12, nine, and four were rated as class I (low risk for bias), class II, and class III, respectively. The researchers developed recommendations for each intervention. For eligible adults presenting to the emergency department with a migraine attack, without contraindications, the recommendations indicate prochlorperazine IV and greater occipital nerve blocks must be offered, while hydromorphone IV must not be offered. Chlorpromazine IV, dexamethasone IV, and valproate IV may be offered, while acetaminophen IV may not be offered. For patients closely matching the clinical trial population only, eptinezumab should be offered, but is rated level U (no recommendation for an emergency department-specific population). For caffeine, granisetron, ibuprofen, ketamine, lidocaine, normal saline, propofol, and SPG blocks, additional evidence is needed and all are rated level U. "These guidelines formally recommend nerve blocks as an evidence-based treatment for acute migraine attacks in the emergency department," Robblee said in a statement. "Integrating this option into practice can offer patients faster pain relief and expand the tools available to emergency clinicians." Several authors disclosed ties to the biopharmaceutical industry. Abstract/Full Text