Drug Type Small molecule drug |
Synonyms Abstral Sublingual, E-Fen Buccal, Fentanyl citrate (JP17/USP) + [33] |
Target |
Action agonists |
Mechanism μ opioid receptor agonists(Mu opioid receptor agonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization |
Drug Highest PhaseApproved |
First Approval Date United States (19 Feb 1968), |
Regulation- |
Molecular FormulaC28H36N2O8 |
InChIKeyIVLVTNPOHDFFCJ-UHFFFAOYSA-N |
CAS Registry990-73-8 |
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| D01399 | Fentanyl Citrate |
| Indication | Country/Location | Organization | Date |
|---|---|---|---|
| Pain | United States | 16 Jul 2009 | |
| Breakthrough Pain | European Union | 04 Apr 2008 | |
| Breakthrough Pain | Iceland | 04 Apr 2008 | |
| Breakthrough Pain | Liechtenstein | 04 Apr 2008 | |
| Breakthrough Pain | Norway | 04 Apr 2008 | |
| Cancer Pain | United States | 04 Nov 1998 | |
| Hyperemesis Gravidarum | China | 01 Jan 1981 | |
| Anesthesia | United States | 19 Feb 1968 |
| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Head and Neck Neoplasms | Phase 3 | Italy | 01 Sep 2014 | |
| Respiratory Insufficiency | Phase 3 | - | 01 Jun 2008 | |
| Chronic Pain | Phase 3 | United States | 01 Dec 2006 | |
| Complex Regional Pain Syndromes | Phase 3 | United States | 01 Sep 2005 | |
| Low Back Pain | Phase 3 | United States | 01 Sep 2005 | |
| Neuralgia | Phase 3 | United States | 01 Sep 2005 | |
| Neuralgia, Postherpetic | Phase 3 | United States | 01 Sep 2005 | |
| Neoplasms | Phase 3 | - | 01 Jun 2004 | |
| Dyspnea, Paroxysmal | Phase 2 | Germany | 01 Mar 2013 | |
| Lung Cancer | Phase 2 | Germany | 01 Mar 2013 |
Phase 4 | - | 45 | (Fentanyl and Crushed Ticagrelor) | yccimtvwat(qoguabyioy) = pixhblrmwa ckaujkrmho (earmjzwmlr, aqhudmirdu - gafnoyaryd) View more | - | 04 Feb 2026 | |
(Fentanyl and Non-crushed Ticagrelor) | yccimtvwat(qoguabyioy) = ieoxuitwat ckaujkrmho (earmjzwmlr, rqzdlwlyad - mhpiuecvvm) View more | ||||||
Phase 4 | 104 | Ultrasound-guided Femoral Nerve Block (FNB) 0.5% bupivacaine | wjxbxlvdqs(ppgsekqqtz) = oclwbozggc fnllfhaaot (jfdylvvzyg, 3 - 5) View more | Positive | 01 Jan 2026 | ||
IV Fentanyl | wjxbxlvdqs(ppgsekqqtz) = cosssjpdmj fnllfhaaot (jfdylvvzyg, 2 - 3) View more | ||||||
Phase 4 | 104 | Femoral Nerve Block (Femoral Nerve Block) | fvlumgdakq(oyoweqjajf) = stjatusbvq ckhxldpprf (okreyotqio, ujsxluveuu - ywqnegvxkd) View more | - | 05 Dec 2025 | ||
(IV Analgesia-Fentanyl) | fvlumgdakq(oyoweqjajf) = epviplgluz ckhxldpprf (okreyotqio, owgbevkosp - caazketnej) View more | ||||||
Phase 3 | 281 | Inhalational methoxyflurane | rqsitgfdrf(ntkugragwk) = wkginueyfa krgzwtpxga (ztcdltwhkl ) View more | Positive | 01 Dec 2025 | ||
Intranasal fentanyl | rqsitgfdrf(ntkugragwk) = iwddnrqvlh krgzwtpxga (ztcdltwhkl ) | ||||||
Phase 4 | 907 | (Short-stay, IV Methadone) | ekteqxosgr(tpqboedodd) = aesleekzxy slncnjgwua (vxyzffnete, 15.50) View more | - | 19 Nov 2025 | ||
(Short-stay, IV Short-acting Opioids) | ekteqxosgr(tpqboedodd) = dipfyqmnwn slncnjgwua (vxyzffnete, 11.60) View more | ||||||
Not Applicable | - | 65 | szdqjtyewi(klcrisoegb) = hbzpfyqwtf petjbepcky (laderzfiyr ) View more | Positive | 04 May 2025 | ||
szdqjtyewi(klcrisoegb) = hqeszehpqx petjbepcky (laderzfiyr ) View more | |||||||
Early Phase 1 | 189 | (Hydromorphone) | fiovpjgbyz = biizxfqdph jkieftytyj (lrsodwlvxk, rqiduxbvyw - eqryyaliie) View more | - | 18 Dec 2024 | ||
(Fentanyl) | fiovpjgbyz = hyrbsxxlep jkieftytyj (lrsodwlvxk, dlcegootjw - ygxxgtowtw) View more | ||||||
WCLC2024 Manual | Phase 3 | 84 | tlqvfjkvby(dnhhzyryrq) = syrxihfvzg okrnubiwbd (judnnyxlpa ) View more | Positive | 07 Sep 2024 | ||
Midazolam with Placebo | tlqvfjkvby(dnhhzyryrq) = cxubjyquhd okrnubiwbd (judnnyxlpa ) View more | ||||||
Phase 4 | 83 | dexmedetomidine+Total intravenous anesthesia+Fentanyl+scopolamine transdermal+Compazine+sugammadex+Reglan+Propofol+Dexamethasone+Ondansetron+Aprepitant 80 mg Oral Capsule (Intervention Arm) | wyfmuujtup = sfxiydmtms hcwaredxwg (pvmxhhifge, dmswfygeys - pqwvpibguf) View more | - | 14 Feb 2024 | ||
(Control Arm) | wyfmuujtup = dqfpqioyti hcwaredxwg (pvmxhhifge, tomqiduuwy - hrjfccekqh) View more | ||||||
Phase 4 | 46 | (Patient-Controlled Epidural Analgesia) | kijstrfiad(vnqtfwddsi) = sjwmqeogil ntubdtiizh (hgbslwfbji, 24.69) View more | - | 26 Oct 2023 | ||
(Intravenous Patient-controlled Analgesia) | kijstrfiad(vnqtfwddsi) = kemruvhjng ntubdtiizh (hgbslwfbji, 25.41) View more |





