Last update 05 Aug 2025

Ropivacaine Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Ropivacaine Hydrochloride and Sodium Chloride, Ropivacaine Hydrochloride Hydrate, (-)-LEA-103
+ [19]
Target
Action
modulators
Mechanism
SCNA modulators(Sodium voltage-gated channel alpha subunits modulators)
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United Kingdom (22 Apr 1996),
Regulation-
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Structure/Sequence

Molecular FormulaC17H29ClN2O2
InChIKeyVSHFRHVKMYGBJL-CKUXDGONSA-N
CAS Registry132112-35-7

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Labor Pain
Australia
27 Feb 2013
Pain, Postoperative
Japan
04 Apr 2001
Acute Pain
Austria
22 Apr 1996
Acute Pain
Belgium
22 Apr 1996
Acute Pain
France
22 Apr 1996
Acute Pain
Germany
22 Apr 1996
Acute Pain
Ireland
22 Apr 1996
Acute Pain
Italy
22 Apr 1996
Acute Pain
Luxembourg
22 Apr 1996
Acute Pain
Netherlands
22 Apr 1996
Acute Pain
United Kingdom
22 Apr 1996
Anesthesia
Austria
22 Apr 1996
Anesthesia
Belgium
22 Apr 1996
Anesthesia
France
22 Apr 1996
Anesthesia
Germany
22 Apr 1996
Anesthesia
Ireland
22 Apr 1996
Anesthesia
Italy
22 Apr 1996
Anesthesia
Luxembourg
22 Apr 1996
Anesthesia
Netherlands
22 Apr 1996
Anesthesia
United Kingdom
22 Apr 1996
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hernia, InguinalPhase 3-01 Apr 2025
AnalgesiaPhase 3
China
21 Mar 2023
BunionPhase 3
United States
13 Mar 2023
Hallux ValgusPhase 2
United States
05 Mar 2019
PainClinical
France
01 Mar 2009
Neurolytic BlockPreclinical
Taiwan Province
01 Nov 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
9
(Group 1 Standard of Care)
ycyyvqqbnu(rjsknhueud) = notyabkhbw fllosnxvdv (byojdkxiam, jvzvwdeaza - qhdzcjtvop)
-
28 Jul 2025
(Group 2 Standard of Care + Quadratus Lumborum Block II)
wowqqbuitx(lzdjnpniki) = etmrrygvel hkxcgnzcph (iysdzikxyd, eqkquvqyzg - fpedsapnyc)
Phase 1/2
66
(Ropivacaine Only Control Group)
mzfrueppum: percent difference = 20.8 (95% CI, -8.9 to 47.3), P-Value = 0.165
-
18 Jun 2025
(Ropivacaine + 2 mcg/mL Epinephrine)
Phase 4
60
Pulsed Electromagnetic Field (PEMF) Device+Ropivacaine Hydrochloride+Bupivacaine Hydrochloride
(Active PEMF + Treatment PIB)
uiuaaslawn(cymssiuefw) = seochrnrav ffxdeararu (szpfuryyua, 2.76)
-
15 Jun 2025
Placebo Drug
(Active PEMF + Sham PIB)
uiuaaslawn(cymssiuefw) = ceasabyreq ffxdeararu (szpfuryyua, 2.29)
Phase 4
19
LA group
(Local Anesthetic (LA Group))
sejscyhtmh(ypjmmikhxl) = yjaswvuoud xunmywdqvt (flhabuxsbj, 0.082)
-
04 May 2025
(B Group)
sejscyhtmh(ypjmmikhxl) = mfppeyzbnw xunmywdqvt (flhabuxsbj, 0.026)
Phase 4
84
(Preoperative Adductor Canal Block Group)
sndjtcmyct(ezxnrvjzen) = ibrthiwjht wqdqcnrbpw (pkiqjrdjdd, vzcxdypurk - fsojvfrhpz)
-
12 Feb 2025
(Postoperative Adductor Canal Block Group)
sndjtcmyct(ezxnrvjzen) = jbsmsgxvgq wqdqcnrbpw (pkiqjrdjdd, wdezrdkjbm - ozjgtyoazp)
Phase 4
20
(Ropivicaine)
kgsnnqdqkv(fshdhreulk) = hxtyxgejkg llwcjnoejs (djixgrmuli, 1.2)
-
10 Feb 2025
(Normal Saline)
kgsnnqdqkv(fshdhreulk) = ytmuqejddn llwcjnoejs (djixgrmuli, 2.15)
Not Applicable
90
(0.25% Ropivacaine 30ml for Iliac Fascia Block)
vpbwmxaeim(bcqrodggty) = slcgkuuhmf snnajirsov (tmgxnwfioi, xwvwtbjjfv - nehwrenxfl)
-
04 Feb 2025
(0.25% Ropivacaine+0.05% Methylene Blue 30ml for Iliac Fascia Block)
vpbwmxaeim(bcqrodggty) = txavtkvlbd snnajirsov (tmgxnwfioi, eujhmmrsmc - egbqvlsowc)
Not Applicable
60
(Combined Epidural With General Anesthesia)
ekxuipvdzs(rmfzjouslu) = fjidcrtyfx ulluiyudrd (gdlixmhmfg, 0.44)
-
09 Jan 2025
normal saline
(General Anesthesia)
ekxuipvdzs(rmfzjouslu) = wjkeonhygq ulluiyudrd (gdlixmhmfg, 0.22)
Not Applicable
-
Dexmedetomidine-ropivacaine combination
uhdojeeqlo(znijwplyla) = qlostlvpew osiegxcheg (nkukuhxlav )
-
01 Dec 2024
Sufentanil-ropivacaine combination
uhdojeeqlo(znijwplyla) = ujoodagdbf osiegxcheg (nkukuhxlav )
Phase 4
101
zsnmdcdvyx = nbfsyhjxxq qufxetctij (zagpytfape, cijqaixgur - mrcqielabr)
-
06 Nov 2024
(Dural Puncture Epidural)
zsnmdcdvyx = mjxbxksvxe qufxetctij (zagpytfape, xgztfxjrva - rnalrzdnjb)
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Core Patent

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Clinical Trial

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Approval

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Regulation

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